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PTVS causes slowdown of debug menu for all project types (C#, Python, Node.js, etc)
PTVS 2.1, any recent build (May 2014)
Start a new instance of VS
Create a C#, Python or Node.js project
Check task manager, make sure that VS is idle
Click on the debug menu
Result: You'll have to wait some time before the menu appears. On my machine (2 core, 4GB ram) it takes 3-5 secs.
To repeat, you'll need to close VS, as subsequent clicks on the debug menu are fast.
I've verified that this is caused by PTVS, and PTVS only (NTVS doesn't seem to cause it). Uninstall PTVS and you won't see the slowdown for C# projects.