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PTVS projects are sensitive to slash directionality
PTVS can't find Python files if the direction of slashes (forward slash vs. back slash) in the .pyproj file and the interpreter's file load call differs. I will attach a screenshot of the feedback dialog when failing to finding the file, as well as my
example program of the error. The funny thing is that "Source search information" says that it found the file, and in the right location.
I have tried this with PTVS 2.0 with VS2012 and 2.1 Beta with VS2013 Express.
EDIT: This issue has been fixed and works in dev builds from 9th of May or newer.