When one installs PTVS 2.0 Alpha and IronPython 2.7 (with VS tooling) side by side, he or she is warned at VS startup that one of the two needs to be removed, with guidance to uninstall IronPython. When I tried to follow the guidance and uninstalled IronPython (from add/remove programs), although uninstall appeared to complete, it left VS in a state where Python projects open, but there is no intellisense. When I then tried uninstalling PTVS to start fresh, afterward I could still open Python projects, but with no intellisense.

I found that I could get out of this situation by doing the following:

• install IronPython (with VS tooling)
• uninstall IronPython
• install PTVS
  

This gave me intellisense in my Python projects.

Subsequently installing IronPython, without VS tooling, allowed me to work with the IronPython interpreters for my projects.