I can confirm I have exactly same issue.
This happened only after installing the ironpkg-220.127.116.11.py file and downloading and installing the associated numpy and scipy files included in the package.
Basically I can't create any of the IronPython project anymore. (File/ New / Project).
The regular Python projects (not ironpython) still works.
PythonContext 18.104.22.168 on .NET 4.0.30319.1
I have the same error message: Exception has been thrown by the target of an invocation
I also confirm the following: Invoking ipy with the X:Frames, numpy and scipy function properly in the ipy console.
I uninstalled and reinstalled IronPython 2.7 without the ironpkg file, after deleting the numpy and scipy files and i could create new project again. After reinstalling ironpkg same issue as before.
Any help would be greatly appreciated,